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The PRINCIPLE trial platform is a national priority trial to find treatments for COVID-19. It is now a country-wide trial, and the only national priority platform trial in primary care. 

The trial is designed to test a range of treatments in the community, with treatment arms that can be stopped, replaced or added.

PRINCIPLE is currently evaluating usual care alone versus usual care plus azithromycin; or usual care plus doxycycline. Azithromycin is a commonly used antibiotic that is anti-inflammatory, treats community-acquired pneumonia and bacterial chest infections, and has antiviral properties. Doxycycline is another commonly used antibiotic.

The trial is being run by the University of Oxford and is funded by UK Research and Innovation and the Department for Health and Social Care through the National Institute for Health Research.

Aim of this trial: 

We aim to find treatments for COVID-19 for people in the community who are at higher risk of complications. We want to find medicines that can help people get better quickly and stop them needing to go to hospital.

More details are at :

If your practice is interested in participating in this trial please email:


Research Project

The Hammersmith and Fulham GP Federation are working together with the Clinical Research Network (CRN), and The National Institute for Health Research (NIHR) to conduct studies/research within Hammersmith and Fulham GP practices. The NIHR fund health care research and translate discoveries into practical products, treatments, devices and procedures, involving patients and the public in all our work. 


To improve the health and wealth of the nation through research.


To provide a health research system in which the NHS supports outstanding individuals working in world-class facilities, conducting leading-edge research focused on the needs of patients and the public.


  • Establish the NHS as an internationally recognised centre of research excellence
  • Attract, develop and retain the best research professionals to conduct people-based research
  • Commission research focused on improving health and social care
  • Strengthen and streamline systems for research management and governance
  • Increase the opportunities for patients and the public to participate in, and benefit from, research
  • Promote and protect the interests of patients and the public in health research
  • Drive faster translation of scientific discoveries into tangible benefits for patients
  • Maximise the research potential of the NHS to contribute to the economic growth of the country through the life sciences industry
  • At as sound custodians of public money for the public good

Patient benefits

Research programme aims to have an impact on the health and wellbeing of patients and users of the NHS and social care. 

For some research studies there are clear outcomes which will benefit patients, often demonstrated by clinical trials which may show a particular intervention is more effective than current treatment options. Ideally this leads to a roll out in the NHS for a wider patient benefit and informs guidelines to influence future practice.

The pathway to patient benefit is not always as straightforward or immediate, and the programme funds a broad range of research which ultimately leads to patient benefit, be it directly or indirectly.

For more information please email